Philipp Christen . Rolf Jaussi . Roger Benoit

Biochemie und Molekularbiologie

Eine Einführung mit 40 Lerneinheiten

14 Glykolyse und Citratzyklus

Inhaltsverzeichnis

Einführung Website

Stoffwechseltabelle Roche (Zenodo, DOI 10.5281/zenodo.4446228)

14.1 Glykolytischer Abbauweg

14.2 Von Pyruvat zu Acetyl-CoA

14.3 Abbau von Acetyl-CoA im Citratzyklus

Weiterführende Literatur

Links

14.1 Glykolytischer Abbauweg

Glycolysis (hhmi BioInteractive; biointeractive.org): Übersicht zur Glykolyse

Glykolyse (Wikipedia)

NAD⁺ (Biplex)

NADH (Biplex)

14.2 Von Pyruvat zu Acetyl-CoA

Pyruvate dehydrogenase complex (Goodsell, RCSB PDB)

Pyruvate dehydrogenase animation (Howard Hughes Medical Institute): Animation der Reaktionen der Pyruvat-Dehydrogenase

Pyruvate dehydrogenase (Wikipedia): Regulation des PDH-Komplexes durch PD-Phosphatase und PD-Kinase

14.3 Abbau von Acetyl-CoA im Citratzyklus

Hans Krebs (nobelprize.org): Kurze Biografie von Hans Krebs, dem Entdecker des Citratzyklus

Citric acid cycle (Howard Hughes Medical Institute): Animation zum Citratzyklus

Anaplerotic reactions of the TCA cycle (sigmaaldrich.com): Anaplerotische Reaktionen des Citratzyklus

Weiterführende Literatur

Chandel 2021, Cold Spring Harb Perspect Biol - "Glycolysis"

Yusri et al. 2025, NPJ Metab Health Dis - "The role of NAD⁺ metabolism and its modulation of mitochondria in aging and disease"

Kierans and Taylor 2024, J Biol Chem - "Glycolysis: A multifaceted metabolic pathway and signaling hub"

Liu et al. 2025, Signal Transduct Target Ther - "Energy metabolism in health and diseases"

Neumann 2022, LaborJournal - "Zyklusvariationen"

Verschueren et al. 2019, Nature - "Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle"

Westermann und Klecker 2022, BIOspektrum - "Hefe Saccharomyces cerevisiae - Mikrobe des Jahres 2022"

Gray et al. 2013, Cell Mol Life Sci - "Regulation of pyruvate metabolism and human disease"

Akram 2013, Cell Biochem Biophys - "Citric acid cycle and role of its intermediates in metabolism"

Cecchini 2003, Annu Rev Biochem - "Function and structure of complex II of the respiratory chain"

Divakaruni and Murphy 2012, Science - "A mitochondrial mystery, solved"

Dastmalchi and Facchini 2016, Science - "Plant metabolons assembled on demand"

Bricker et al. 2012, Science "A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans"

Herzig et al. 2012, Science - "Identification and functional expression of the mitochondrial pyruvate carrier"

Kornberg 2000, Nat Rev Mol Cell Biol - "Krebs and his trinity of cycles"

Revision August 2026