Philipp Christen  .  Rolf Jaussi .  Roger Benoit

Biochemie und Molekularbiologie

Eine Einführung mit 40 Lerneinheiten




15   ATP-Synthese in Mitochondrien


Inhaltsverzeichnis

Einführung Website

Merksätze

Kontrollfragen

Stoffwechseltabelle Roche (Zenodo, DOI 10.5281/zenodo.4446228)

15.1 Organisation der Atmungskette

15.2 Redoxkomponenten der Atmungskette (FMN, FAD, FeS-Zentren, Ubichinon, Cytochrome)

15.3 Chemiosmotischer Mechanismus der oxidativen Phosphorylierung

15.4 Transport von Reduktionsäquivalenten vom Cytosol in die Mitochondrien

15.5 ATP-Bilanz des oxidativen Abbaus von Glucose

15.6 Regulation der mitochondrialen ATP-Synthese

Weiterführende Literatur

Links

15.1 Organisation der Atmungskette

Electron transport chain (HHMI biointeractive)

Cellular respiration hub (HHMI Biointeractive)

Succinate dehydrogenase (Wikipedia): Komplex II

Electron transport chain animation (YouTube): Animation zur Elektronentransport-Kette

Mitochondria, metabolism, and cell behavior (iBiology): Vortrag zur Struktur und Funktion der Mitochondrien

15.2 Redoxkomponenten der Atmungskette (FMN, FAD, FeS-Zentren, Ubichinon, Cytochrome)

Complex I (David S. Goodsell, RCSB PDB): Komplex I

Cytochrome c (David S. Goodsell, RCSB PDB): Cytochrom c

Cytochrome c oxidase (David S. Goodsell, RCSB PDB): Cytochrom c-Oxidase

NAD+ (Biplex)

Hämtypen (Wikipedia): Strukturen der Häme

Oxidationswasser beim Abbau der verschiedenen Nährstoffe (Lexikon der Biologie)

15.3 Chemiosmotischer Mechanismus der oxidativen Phosphorylierung

ATP synthase (RCSB PDB): Animation

Molecular animations of ATP synthase (Walker group, https://www.mrc-mbu.cam.ac.uk/)

ATP Synthase (David S. Goodsell, RCSB PDB): ATP-Synthase

Uncoupling electron transport from ATP synthesis (LibreTexts Biology): Entkoppler und Inhibitoren der ATP-Synthese

ATP synthesis (HHMI biointeractive): Animation der ATP-Produktion

Braunes Fettgewebe (ardmediathek.de; NDR1)

Chemiosmotischer Mechanismus der mitochondrialen ATP-Synthese

15.4 Transport von Reduktionsäquivalenten vom Cytosol in die Mitochondrien

Malate-aspartate shuttle (Bhattacharjee, YouTube): Kurze Vorlesung

15.5 ATP-Bilanz des oxidativen Abbaus von Glucose

Zellatmung (Wikipedia): Oxidation von Glucose

15.6 Regulation der mitochondrialen ATP-Synthese

ATP-ADP translocase (Wikipedia): ATP-ADP-Translokator

Pasteureffekt

Weiterführende Literatur

Lai et al. 2023, Mol Cell - "Structure of the human ATP synthase"

Pinke et al. 2020, Nat Struct Mol Biol - "Cryo-EM structure of the entire mammalian F-type ATP synthase"

Mühleip et al. 2019, eLife - "Structure of a mitochondrial ATP synthase with bound native cardiolipin"

Zheng et al. 2024, Nature - "High-resolution in situ structures of mammalian respiratory supercomplexes"

Waltz et al. 2025, Science - "In-cell architecture of the mitochondrial respiratory chain"

Nakagano et al. 2026, Nat Commun - "Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane"

Kühlbrandt et al. 2025, Annu Rev Biophys - "Cryo-EM of Mitochondrial Complex I and ATP Synthase"

Bochkova et al. 2025, Biophys Rev - "The flexible chain: regulation of structure and activity of ETC complexes defines rate of ATP synthesis and sites of superoxide generation"

Townsend and Tseng 2014, Trends Endocrinol Metab - "Brown fat fuel utilization and thermogenesis"

Buttgereit and Brand 1995, Biochem J - "A hierarchy of ATP-consuming processes in mammalian cells"

Cross 2019, Nature - "Paul Delos Boyer (1918-2018)" - Nachruf für den Entdecker des Mechanismus der ATP-Synthase

Kampjut and Sazanov 2020, Science - "The coupling mechanism of mammalian respiratory complex I"

Terada 1990, Environ Health Perspect - "Uncouplers of oxidative phosphorylation"

Lu et al. 2008, J Theor Biol - "Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia"

Locasale and Cantley 2011, Cell Metab - "Metabolic flux and the regulation of mammalian cell growth"

Mazat et al. 2013, IUBMB Life - "Mitochondrial energetic metabolism-some general principles"

Arnold 2012, Mitochondrion - "The power of life--cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival"


Revision September 2026