Philipp Christen . Rolf Jaussi . Roger Benoit

	Signal recognition particle (dnatube.com): Animation zur Funktionsweise des "Signal Recognition Particle" Organization and segregation of bacterial chromosomes (Wang et al 2013, Nat Rev Genet 14, 191-203): EM-Bilder von bakteriellen Nucleoiden Comparing prokaryotic and eukaryotic cells (courses.lumenlearning.com): Vergleich von prokaryontischen und eukaryontischen Zellen Eukaryonten und Prokaryonten (http://www.biologie-schule.de)

22.2 Kompartimente der Eukaryontenzellen

Eukaryotic cells (Scitable): Kompartimente der Eukaryontenzellen

Miniaturbildübersicht Sekretvesikel (Electron microscopic atlas, H. Jastrow, www.drjastrow.de)

Electron microscopy atlas (H. Jastrow, www.drjastrow.de): EM-Bilder der verschiedenen Zellkompartimente

Protein targeting (Cdlinfermieristica, YouTube)

	Eukaryotic cells (Scitable): Kompartimente der Eukaryontenzellen Miniaturbildübersicht Sekretvesikel (Electron microscopic atlas, H. Jastrow, www.drjastrow.de) Electron microscopy atlas (H. Jastrow, www.drjastrow.de): EM-Bilder der verschiedenen Zellkompartimente Protein targeting (Cdlinfermieristica, YouTube)

22.3 Mechanismen des intrazellulären Proteintransports

Directing traffic: how vesicles transport cargo (learn.genetics.utah.edu): Video und Erklärungen zum Transport via Vesikel

Clathrin (David S. Goodsell, RCSB PDB): Struktur und Funktion des Clathrins

Inner Life of the Cell (AP120 Dr. Tydell, YouTube): Vesikel wird von Motorprotein entlang Microtubuli gezogen

	Directing traffic: how vesicles transport cargo (learn.genetics.utah.edu): Video und Erklärungen zum Transport via Vesikel Clathrin (David S. Goodsell, RCSB PDB): Struktur und Funktion des Clathrins Inner Life of the Cell (AP120 Dr. Tydell, YouTube): Vesikel wird von Motorprotein entlang Microtubuli gezogen

22.4 Proteintransport im Golgi-Apparat

How do proteins move through the Golgi apparatus? (Connerly 2010,Nature Education 3(9):60): Wie bewegen sich Proteine durch den Golgi-Apparat?

Golgi apparatus of a reticular cell from a human pharyngeal tonsil (Electron microscopic atlas, H. Jastrow, www.uni-mainz.de): EM-Bild eines Golgi-Apparats

	How do proteins move through the Golgi apparatus? (Connerly 2010,Nature Education 3(9):60): Wie bewegen sich Proteine durch den Golgi-Apparat? Golgi apparatus of a reticular cell from a human pharyngeal tonsil (Electron microscopic atlas, H. Jastrow, www.uni-mainz.de): EM-Bild eines Golgi-Apparats

22.5 Proteintransport zwischen Golgi-Apparat, Zelloberfläche und Lysosomen

Endoplasmic reticulum, Golgi apparatus, and lysosomes (Scitable, Nature Education): Transport von Proteinen in die Zelle hinein und aus der Zelle heraus (Figure 2)

	Endoplasmic reticulum, Golgi apparatus, and lysosomes (Scitable, Nature Education): Transport von Proteinen in die Zelle hinein und aus der Zelle heraus (Figure 2)

22.6 Proteinglykosylierung während Transport durch ER und Golgi-Apparat

Blutgruppen und Rhesus-Antigene (Springer Lexikon Medizin)

Glykosylierung von Proteinen (Wikipedia)

Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum, Figures and Data (Braunger et al. 2018, Science)

Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes (Braunger et al. 2018, Science, RCSB PDB): Struktur
Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome (Braunger et al. 2018, Science, RCSB PDB): Struktur
Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome (Braunger et al. 2018, Science, RCSB PDB): Struktur

	Blutgruppen und Rhesus-Antigene (Springer Lexikon Medizin) Glykosylierung von Proteinen (Wikipedia) Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum, Figures and Data (Braunger et al. 2018, Science) Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes (Braunger et al. 2018, Science, RCSB PDB): Struktur Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome (Braunger et al. 2018, Science, RCSB PDB): Struktur Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome (Braunger et al. 2018, Science, RCSB PDB): Struktur

22.7 Import von Proteinen in Mitochondrien, Chloroplasten und Peroxisomen

Proteintransport in Mitochondrien: TOM- und TIM-Komplexe (Schlaglicht, pubman.mpdl.mpg.de): PDF Dokument

	Proteintransport in Mitochondrien: TOM- und TIM-Komplexe (Schlaglicht, pubman.mpdl.mpg.de): PDF Dokument

22.8 Pförtner-kontrollierter Transport (Gated transport) durch die Kernhülle

New close-up views of the nuclear pore complex (Chemical&Engineering News; https://cen.acs.org): Aktuelles Modell des Kernporenkomplexes

The nuclear pore complex (Tim Isgro and Lingling Miao, www.ks.uiuc.edu): Struktur und Funktion des Kernporenkomplexes

Nuclear pore complex (Samir Patel, YouTube): Struktur und Dynamik eines Kernporenkomplexes

Miniaturbildübersicht Kernpore (Electron microscopic atlas, H. Jastrow, www.drjastrow.de): EM-Bilder von Kernporen

	New close-up views of the nuclear pore complex (Chemical&Engineering News; https://cen.acs.org): Aktuelles Modell des Kernporenkomplexes The nuclear pore complex (Tim Isgro and Lingling Miao, www.ks.uiuc.edu): Struktur und Funktion des Kernporenkomplexes Nuclear pore complex (Samir Patel, YouTube): Struktur und Dynamik eines Kernporenkomplexes Miniaturbildübersicht Kernpore (Electron microscopic atlas, H. Jastrow, www.drjastrow.de): EM-Bilder von Kernporen

22.9 Kontrolle der Faltung und der Lokalisierung von Proteinen durch molekulare Chaperone und Proteasomen

Proteasome (David S. Goodsell, RCSB PDB): Struktur und Funktion der Proteasomen

Ubiquitin (David S. Goodsell, RCSB PDB): Struktur und Funktion von Ubiquitin

	Proteasome (David S. Goodsell, RCSB PDB): Struktur und Funktion der Proteasomen Ubiquitin (David S. Goodsell, RCSB PDB): Struktur und Funktion von Ubiquitin

Weiterführende Literatur

	Akarsu et al. 2022, Nature - "Defining mitochondrial protein functions through deep multiomic profiling" McBride and Frost 2016, Nature - "Cell biology: Double agents for mitochondrial division" Rensvold et al. 2022, Nature - "Defining mitochondrial protein functions through deep multiomic profiling" Balsera et al. 2009, Cell Mol Life Sci - "Protein import machineries in endosymbiotic organelles" Pennisi 2014, Science - "Microbiology. Modern symbionts inside cells mimic organelle evolution" Wu et al. 2019, Nature - "Structure of the post-translational protein translocation machinery of the ER membrane" Wu et al. 2019, Nature - "Structure of the post-translational protein translocation machinery of the ER membrane" Soykan and Haucke 2016, Nature - "Cell biology: Membrane kiss mediates hormone secretion" Zimmermann 2022, BIOspektrum - "Mechanismen des Proteinimports in das humane endoplasmatische Retikulum" Brandizzi and Barlowe 2013, Nat Rev Mol Cell Biol - "Organization of the ER-Golgi interface for membrane traffic control" Luzio et al. 2007, Nat Rev Mol Cell Biol - "Lysosomes: fusion and function" Pool 2016, Nature - "Cell biology: Sort of unexpected" Braunger et al. 2018, Science - "Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum" Dalziel et al. 2014, Science - "Emerging principles for the therapeutic exploitation of glycosylation" Scudellari 2019, Nature - "Protein-slaying drugs could be the next blockbuster therapies" Schwartz 2022, Science - "Solving the nuclear pore puzzle" Hua and Vierstra 2011, Annu Rev Plant Biol - "The cullin-RING ubiquitin-protein ligases" Vierstra 2009, Nat Rev Mol Cell Biol - "The ubiquitin-26S proteasome system at the nexus of plant biology" Pohl and Dikic 2019, Science - "Cellular quality control by the ubiquitin-proteasome system and autophagy" Balchin et al. 2016, Science - "In vivo aspects of protein folding and quality control" Revision June 2024

Akarsu et al. 2022, Nature - "Defining mitochondrial protein functions through deep multiomic profiling"

McBride and Frost 2016, Nature - "Cell biology: Double agents for mitochondrial division"

Rensvold et al. 2022, Nature - "Defining mitochondrial protein functions through deep multiomic profiling"

Balsera et al. 2009, Cell Mol Life Sci - "Protein import machineries in endosymbiotic organelles"

Pennisi 2014, Science - "Microbiology. Modern symbionts inside cells mimic organelle evolution"

Wu et al. 2019, Nature - "Structure of the post-translational protein translocation machinery of the ER membrane"

Soykan and Haucke 2016, Nature - "Cell biology: Membrane kiss mediates hormone secretion"

Zimmermann 2022, BIOspektrum - "Mechanismen des Proteinimports in das humane endoplasmatische Retikulum"

Brandizzi and Barlowe 2013, Nat Rev Mol Cell Biol - "Organization of the ER-Golgi interface for membrane traffic control"

Luzio et al. 2007, Nat Rev Mol Cell Biol - "Lysosomes: fusion and function"

Pool 2016, Nature - "Cell biology: Sort of unexpected"

Braunger et al. 2018, Science - "Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum"