Philipp Christen . Rolf Jaussi . Roger Benoit

	Protein structure animation (YouTube): Kurze Animation über die Hierarchie der Proteinfaltung mit Erklärungen Protein folding animation (YouTube): Kurze Animation über Proteinfaltung Protein structure (Scitable, Nature Education) General principles of membrane protein folding and stability (Stephen White laboratory): Kurze Übersicht zur Faltung von Membranproteinen To online macromolecular museum (Callutheran.edu): Sammlung von wichtigen Proteinstrukturen mit 3D Ansichten und Erklärungen

3.2 Sekundärstruktur

Secondary structure (YouTube): Animation zur Sekundärstruktur

	Secondary structure (YouTube): Animation zur Sekundärstruktur

3.3 Tertiärstruktur

Tertiary structure (YouTube): Animation zur Tertiärstruktur

	Tertiary structure (YouTube): Animation zur Tertiärstruktur

3.4 Äußere Gestalt und Quartärstruktur

Quaternary structure (YouTube): Animation zur Quartärstruktur

Protein structure (YouTube - University of Surrey): Animation zur Proteinstruktur

	Quaternary structure (YouTube): Animation zur Quartärstruktur Protein structure (YouTube - University of Surrey): Animation zur Proteinstruktur

3.5 Dynamik und funktionsgebundene Strukturänderungen

Hemoglobin: Studying the T to R transition (Janet Iwasa): Animationen zu Strukturänderungen von Hämoglobin

Protein folding Animation (YouTube): Animation zur Dynamik der Proteinfaltung

Folding and binding of an intrinsically disordered protein (Bio Comp Pictures, YouTube, J. Chemical Theory and Computation): Animation

	Hemoglobin: Studying the T to R transition (Janet Iwasa): Animationen zu Strukturänderungen von Hämoglobin Protein folding Animation (YouTube): Animation zur Dynamik der Proteinfaltung Folding and binding of an intrinsically disordered protein (Bio Comp Pictures, YouTube, J. Chemical Theory and Computation): Animation

3.6 Denaturierung

Protein denaturation (YouTube): Animation einer Protein-Denaturierung

	Protein denaturation (YouTube): Animation einer Protein-Denaturierung

3.7 Faltungswege

Protein folding (YouTube): Kurze Animation zur Energie-Minimierung bei der Proteinfaltung

Protein folding/stability in vivo and in vitro (Biochemistry Online, Dr. H. Jakubowski): Ausführliche Zusammenfassung der kinetischen und thermodynamischen Aspekte der Proteinfaltung

Chaperones (David S. Goodsell, RCSB PDB): Übersicht zu Struktur und Funktionen von Chaperonen

Heat shock protein information resource (http://pdslab.biochem.iisc.ernet.in/hspir): Hitzeschockproteine

	Protein folding (YouTube): Kurze Animation zur Energie-Minimierung bei der Proteinfaltung Protein folding/stability in vivo and in vitro (Biochemistry Online, Dr. H. Jakubowski): Ausführliche Zusammenfassung der kinetischen und thermodynamischen Aspekte der Proteinfaltung Chaperones (David S. Goodsell, RCSB PDB): Übersicht zu Struktur und Funktionen von Chaperonen Heat shock protein information resource (http://pdslab.biochem.iisc.ernet.in/hspir): Hitzeschockproteine

3.8 Proteinfehlfaltung

Prions (David S. Goodsell, RCSB PDB): Übersicht zu Prionen: Proteine, die in falsch gefalteter Form Krankheiten verursachen können

Amyloids (David S. Goodsell, RCSB PDB)

Human prion protein fragment (PDB): 3-D Struktur eines Fragments eines Prionen Proteins

Stanley B. Prusiner (Nobelprize.org): Kurze Autobiografie des Entdeckers der Prionen

Marfan-Syndrom (Doccheck Flexikon)

	Prions (David S. Goodsell, RCSB PDB): Übersicht zu Prionen: Proteine, die in falsch gefalteter Form Krankheiten verursachen können Amyloids (David S. Goodsell, RCSB PDB) Human prion protein fragment (PDB): 3-D Struktur eines Fragments eines Prionen Proteins Stanley B. Prusiner (Nobelprize.org): Kurze Autobiografie des Entdeckers der Prionen Marfan-Syndrom (Doccheck Flexikon)

3.9 Faserproteine

Low resolution molecular envelope structure of type I collagen (PDB): 3D Struktur von Kollagen

Collagen (David S. Goodsell, RCSB PDB): Übersicht zu Kollagen Funktionen und Struktur

Desmosin-Struktur

Dauerwellen

	Low resolution molecular envelope structure of type I collagen (PDB): 3D Struktur von Kollagen Collagen (David S. Goodsell, RCSB PDB): Übersicht zu Kollagen Funktionen und Struktur Desmosin-Struktur Dauerwellen

Weiterführende Literatur

	Zhang et al. 2025, Curr Opin Struct Biol - "Artificial intelligence methods for protein folding and design" Kortemme 2024, Cell - "De novo protein design-From new structures to programmable functions" Fox et al. 2025, Structure - "Code to complex: AI-driven de novo binder design" Pacesa et al. 2025, Nature - "One-shot design of functional protein binders with BindCraft" Anishchenko et al. 2021, Nature - "De novo protein design by deep network hallucination" Eisenstein 2021, Nature - "Artificial intelligence powers protein-folding predictions" Service 2021, Science - "Protein structures for all" Sugase et al. 2007, Nature - "Mechanism of coupled folding and binding of an intrinsically disordered protein" Chiti and Dobson 2006, Annu Rev Biochem - "Protein misfolding, functional amyloid, and human disease" Cabrita et al. 2010, Curr Opin Struct Biol - "Protein folding on the ribosome" Burgess and Zhang 2013, Nat Struct Mol Biol - "Histone chaperones in nucleosome assembly and human disease" Gupta and Tuteja 2011, Plant Signal Behav - "Chaperones and foldases in endoplasmic reticulum stress signaling in plants" Rothman and Schekman 2011, Cell - "Molecular mechanism of protein folding in the cell" San Martin 2012, Viruses - "Latest insights on adenovirus structure and assembly" Mashaghi et al. 2016, Nature - "Alternative modes of client binding enable functional plasticity of Hsp70" Liu and Craig 2016, Nature - "Molecular biology: Mature proteins braced by a chaperone" Anderson et al. 2016, Nature - "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development" Korte 2019, Science - "Neuronal function of Alzheimer's protein" Kueffer et al. 2016, Nature - "The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6" Focus on neurodegenerative diseases, Nature Neuroscience 2018 Sevigny et al. 2016, Nature - "The antibody aducanumab reduces Aβ plaques in Alzheimer's disease" Revision Januar 2026

Zhang et al. 2025, Curr Opin Struct Biol - "Artificial intelligence methods for protein folding and design"

Kortemme 2024, Cell - "De novo protein design-From new structures to programmable functions"

Fox et al. 2025, Structure - "Code to complex: AI-driven de novo binder design"

Pacesa et al. 2025, Nature - "One-shot design of functional protein binders with BindCraft"

Anishchenko et al. 2021, Nature - "De novo protein design by deep network hallucination"

Eisenstein 2021, Nature - "Artificial intelligence powers protein-folding predictions"

Service 2021, Science - "Protein structures for all"

Sugase et al. 2007, Nature - "Mechanism of coupled folding and binding of an intrinsically disordered protein"

Chiti and Dobson 2006, Annu Rev Biochem - "Protein misfolding, functional amyloid, and human disease"

Cabrita et al. 2010, Curr Opin Struct Biol - "Protein folding on the ribosome"

Burgess and Zhang 2013, Nat Struct Mol Biol - "Histone chaperones in nucleosome assembly and human disease"

Gupta and Tuteja 2011, Plant Signal Behav - "Chaperones and foldases in endoplasmic reticulum stress signaling in plants"